On Dec 9th (local time) 2006 I was onboard the space shuttle Discovery when it launched from Kennedy Space Center in Florida for a mission to the International Space Station (ISS). It was the beginning of a fabulous journey and adventure, with the main goal to continue building ISS for future research and exploration. To some extent is was also a final goal for me: 16 years earlier I had applied to become astronaut, two years later I had been selected – but only now was I finally on my way to space. This story will be told, with pictures and video from space, also from my second space flight in 2009. I will discuss the science and technology on ISS – one could say that ISS is an early application of a total IoT system. The science range from fundamental physics, to biology, to medicine. Astronauts are really guinea pigs in space. The human physiology changes a lot in the weightlessness in space and we need to understand these changes in order to send people safely further and longer into space in the future. There are many developments ongoing, with both new private actors, like Elon Musk´s SpaceX and Richard Branson´s Virgin Galactic, as well as the old big space agencies NASA, ESA etc. I will present some of the major new ideas and share my view of the future for humankind in space.